Cet avis est consultable à partir du lien "Avis du jj/mm/aaaa" ou encore sur demande auprès de la HAS in addition d'informations dans l'aide. Les avis et synthèses d'avis contiennent un paragraphe sur la spot du médicament dans la stratégie thérapeutique.
Résumé de l'avis : Pecfent n'apporte pas d'amélioration de assistance médical rendu (ASMR V) par rapport aux morphiniques d'action rapide indiqués dans la prise en cost des accès douloureux paroxystiques chez les clients adultes utilisant des morphiniques pour traiter des douleurs chroniques d'origine cancéreuse.
Les symptômes attendus d'un surdosage de fentanyl par voie nasale devraient être de même nature que ceux du fentanyl par voie intraveineuse et des autres opioïdes.
The organization that markets PecFent will give instructional products in Each individual EU Member Point out to make sure that individuals, Medical professionals and pharmacists are aware about how PecFent need to be used, the risk of accidental exposure to fentanyl and how to dispose of the medicine.
Dosage Adjustment:Commonly, the dose of PecFent needs to be enhanced when individuals involve more than one dose for every breakthrough soreness episode for a number of consecutive episodes.
Les clients sous traitement opioïde de fond sont ceux prenant au moins 60 mg par jour de morphine par voie orale, au moins twenty five microgrammes par heure de fentanyl transdermique, au moins thirty mg par jour d'oxycodone, au moins 8 mg par jour d'hydromorphone par voie orale ou une dose équianalgésique d'un autre opioïde depuis au moins une semaine.
You have to retain PecFent in the kid resistant storage container when you find yourself not applying it, even When you have utilised all eight sprays. This is because PecFent could possibly be existence-threatening if taken by a kid accidentally.
Remedy with PecFent ought to be started by and keep on being beneath the supervision of a doctor who may have knowledge in running opioid cure in cancer people. The health practitioner need to Bear in mind the opportunity for PecFent to get abused.
Minimized cAMP decreases cAMP dependant inflow of calcium ions to the cell. The exchange of GTP for GDP brings about hyperpolarization of your mobile and inhibition of nerve action.
Should you overlook a dose, get it the moment you bear in mind. If It really is Virtually time to your subsequent dose, skip the skipped dose and keep on using your standard timetable.
Increased infusion charges (around 3 mcg/kg/min) have been Employed in cardiac surgical procedures. PecFent is chemically incompatible While using the induction brokers thiopentone & methohexitone as a result of vast variations in pH
Serious pulmonary ailment: PecFent must be titrated with caution in sufferers with Serious obstructive pulmonary condition or pre-present healthcare disorders predisposing them to respiratory depression.
Re-dosing individuals read more inside of a solitary episode: Dosing could be repeated the moment for the duration of one episode of breakthrough ache if pain will not be adequately relieved by one PecFent dose. Re-dosing may well take place 30 minutes immediately after the start of administration of PecFent and a similar dosage power should be applied.
PecFent is made up of fentanyl, a strong opioid, which operates by binding to your body's opioid receptors to decrease the perception of pain.